Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Sex differences in glutathione metabolism and acetaminophen toxicity Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen ScienceDirect