SciELO Brasil Prevalence of hepatitis C virus genotypes in the State of Par, Brazil Prevalence of hepatitis C virus genotypes in the State of Par, Brazil Melanosis coli** Melanosis coli is a benign, reversible condition characterized by brown black pigmentation of the colonic mucosa, most often due to chronic use of anthraquinone laxatives. The discoloration is caused Generation of hepatitis C virusresistant liver cells by genome editingmediated stable expression of RNA aptamer: Molecular Therapy Methods & Clinical Development Diagnosis, management, and treatment of hepatitis C Strader 2004 Hepatology Wiley Online Library