Hepatic Glutathione Synthesis: The Liver's Antioxidant Powerhouse Glutathione (GSH) is the most abundant intracellular antioxidantand the liver is its primary production site. Through a tightly regulated, ATP dependent pathway, hepatocytes Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression Nature Communications Cells need a steady supply of antioxidants to defend themselves, and glutathione is the body's master defender. Yet, daily stress and ageing can deplete glutathione faster than we can make it. NAC + Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression Nature Communications