Lesional Markers and Precursors of Melanoma Dermatologic Clinics Pigmented Lesions and Melanoma Plastic Surgery KeyPlastic Surgery Key Definition of melanocytic macules associated with Peutz Jeghers syndrome NCI Dictionary of Genetics Terms NCI Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule.