Mechanism of action of Glutathione in the biological system The enzyme Glutathione transferase conjugate Glutathione to fat soluble compound, heavy metal such as Mercury and lead making it water soluble for excretion Glutathione is one of the most important molecules in detoxification. It drives Phase II conjugation and helps neutralize oxidative stress at the cellular level. But detoxification does not end with transformation. It Glutathione an overview ScienceDirect Topics Video: Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation