How to Take Glutathione Effectively: Dosage & Tips What is glutathione? Know as the most important antioxidant in the body, glutathione is an essential antioxidant manufactured in all cells, but primarily in the liver. It is essential because it Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high fat diet fed obese mice Scientific Reports Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression Nature Communications